/* Teaching-content components (MA concepts, RoB 2, GRADE, references).
   App shell, home page and calculators live in layout.css.
   Pruned 2026-09-30: unused selectors removed with PurgeCSS, redesigned components moved to layout.css. */

:root {
    --primary-50: #f0fdfa;
    --primary-100: #ccfbf1;
    --primary-200: #99f6e4;
    --primary-300: #5eead4;
    --primary-400: #2dd4bf;
    --primary-500: #14b8a6;
    --primary-600: #0d9488;
    --primary-700: #0f766e;
    --primary-800: #115e59;
    --primary-900: #134e4a;
    --accent-50: #eff6ff;
    --accent-100: #dbeafe;
    --accent-200: #bfdbfe;
    --accent-300: #93c5fd;
    --accent-400: #60a5fa;
    --accent-500: #3b82f6;
    --accent-600: #2563eb;
    --accent-700: #1d4ed8;
    --accent-800: #1e40af;
    --accent-900: #1e3a8a;
    --gray-50: #f9fafb;
    --gray-100: #f3f4f6;
    --gray-200: #e5e7eb;
    --gray-300: #d1d5db;
    --gray-400: #9ca3af;
    --gray-500: #6b7280;
    --gray-600: #4b5563;
    --gray-700: #374151;
    --gray-800: #1f2937;
    --gray-900: #111827;
    --success: #10b981;
    --warning: #f59e0b;
    --error: #ef4444;
    --info: #3b82f6;
    --font-sans: 'Inter', -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, sans-serif;
    --font-mono: 'JetBrains Mono', 'Fira Code', Consolas, monospace;
    --space-1: 0.25rem;
    --space-2: 0.5rem;
    --space-3: 0.75rem;
    --space-4: 1rem;
    --space-5: 1.25rem;
    --space-6: 1.5rem;
    --space-8: 2rem;
    --space-10: 2.5rem;
    --space-12: 3rem;
    --space-16: 4rem;
    --space-20: 5rem;
    --radius-sm: 0.375rem;
    --radius: 0.5rem;
    --radius-md: 0.75rem;
    --radius-lg: 1rem;
    --radius-xl: 1.5rem;
    --radius-2xl: 2rem;
    --shadow-sm: 0 1px 2px 0 rgba(0, 0, 0, 0.05);
    --shadow: 0 1px 3px 0 rgba(0, 0, 0, 0.1), 0 1px 2px 0 rgba(0, 0, 0, 0.06);
    --shadow-md: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
    --shadow-lg: 0 10px 15px -3px rgba(0, 0, 0, 0.1), 0 4px 6px -2px rgba(0, 0, 0, 0.05);
    --shadow-xl: 0 20px 25px -5px rgba(0, 0, 0, 0.1), 0 10px 10px -5px rgba(0, 0, 0, 0.04);
}

@keyframes fadeIn {
    from {
        opacity: 0;
        transform: translateY(10px);
    }
    to {
        opacity: 1;
        transform: translateY(0);
    }
}

h1 {
    font-size: clamp(2rem, 5vw, 3rem);
    font-weight: 800;
    line-height: 1.2;
    letter-spacing: -0.025em;
}

h2 {
    font-size: clamp(1.5rem, 4vw, 2.25rem);
    font-weight: 700;
    line-height: 1.3;
    letter-spacing: -0.025em;
}

h3 {
    font-size: clamp(1.25rem, 3vw, 1.75rem);
    font-weight: 600;
    line-height: 1.4;
}

h4 {
    font-size: clamp(1.1rem, 2.5vw, 1.375rem);
    font-weight: 600;
    line-height: 1.4;
}

p {
    font-size: 1rem;
    line-height: 1.7;
    color: var(--gray-600);
}

@keyframes float {
    0%, 100% {
        transform: translate(-50%, -50%) rotate(0deg);
    }
    50% {
        transform: translate(-50%, -50%) rotate(180deg);
    }
}

.card {
    background: white;
    border-radius: var(--radius-lg);
    padding: var(--space-6);
    box-shadow: var(--shadow-md);
    border: 1px solid var(--gray-100);
    transition: all 0.3s cubic-bezier(0.4, 0, 0.2, 1);
    position: relative;
    overflow: hidden;
}

.card::before {
    content: '';
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    height: 4px;
    background: linear-gradient(90deg, var(--primary-500), var(--accent-500));
    opacity: 0;
    transition: opacity 0.3s ease;
}

.card:hover {
    transform: translateY(-4px);
    box-shadow: var(--shadow-xl);
    border-color: var(--primary-100);
}

.card:hover::before {
    opacity: 1;
}

@keyframes shimmer {
    0% {
        transform: translateX(-100%);
    }
    100% {
        transform: translateX(100%);
    }
}

@keyframes slideInUp {
    from {
        opacity: 0;
        transform: translateY(30px);
    }
    to {
        opacity: 1;
        transform: translateY(0);
    }
}

@keyframes slideInLeft {
    from {
        opacity: 0;
        transform: translateX(-30px);
    }
    to {
        opacity: 1;
        transform: translateX(0);
    }
}

@keyframes pulse {
    0%, 100% {
        opacity: 1;
    }
    50% {
        opacity: 0.7;
    }
}

@keyframes bounce {
    0%, 20%, 53%, 80%, 100% {
        transform: translate3d(0, 0, 0);
    }
    40%, 43% {
        transform: translate3d(0, -8px, 0);
    }
    70% {
        transform: translate3d(0, -4px, 0);
    }
    90% {
        transform: translate3d(0, -2px, 0);
    }
}

.loading {
    position: relative;
}

.loading::after {
    content: '';
    position: absolute;
    top: 50%;
    left: 50%;
    width: 20px;
    height: 20px;
    margin: -10px 0 0 -10px;
    border: 2px solid var(--primary-200);
    border-top: 2px solid var(--primary-600);
    border-radius: 50%;
    animation: spin 1s linear infinite;
}

@keyframes spin {
    0% {
        transform: rotate(0deg);
    }
    100% {
        transform: rotate(360deg);
    }
}

.reference-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
    gap: 2rem;
}

.reference-card {
    background: white;
    border-radius: 12px;
    padding: 1.5rem;
    box-shadow: 0 4px 15px rgba(0,0,0,0.1);
}

.reference-card h3 {
    color: var(--gray-600);
    margin-bottom: 1rem;
    display: flex;
    align-items: center;
    gap: 0.5rem;
}

.reference-list {
    display: flex;
    flex-direction: column;
    gap: 1rem;
}

.reference-item {
    padding: 1rem;
    background: var(--gray-50);
    border-radius: 8px;
    border-left: 4px solid var(--primary-600);
}

.reference-item strong {
    color: var(--gray-600);
}

.method-accordion {
    display: flex;
    flex-direction: column;
    gap: 0.5rem;
}

.method-item {
    border: 1px solid var(--gray-200);
    border-radius: 8px;
    overflow: hidden;
}

.method-header {
    background: var(--gray-50);
    padding: 1rem;
    cursor: pointer;
    display: flex;
    justify-content: space-between;
    align-items: center;
    font-weight: 500;
    transition: background-color 0.3s ease;
}

.method-header:hover {
    background: var(--gray-200);
}

.method-content {
    padding: 1rem;
    display: none;
    background: white;
    border-top: 1px solid var(--gray-200);
}

.method-content.active {
    display: block;
}

.method-content p {
    margin-bottom: 0.5rem;
}

.method-content strong {
    color: var(--gray-600);
}

.tool-info {
    background: var(--gray-50);
    padding: 1rem;
    border-radius: 8px;
}

.tool-info p {
    margin-bottom: 0.5rem;
}

@media (max-width: 768px) {
    .reference-grid {
        grid-template-columns: 1fr;
    }
}

@keyframes fadeIn {
    from {
        opacity: 0;
        transform: translateY(10px);
    }
    to {
        opacity: 1;
        transform: translateY(0);
    }
}

.loading {
    position: relative;
    pointer-events: none;
}

.loading::after {
    content: '';
    position: absolute;
    top: 50%;
    left: 50%;
    width: 20px;
    height: 20px;
    margin: -10px 0 0 -10px;
    border: 2px solid var(--gray-100);
    border-top: 2px solid var(--primary-600);
    border-radius: 50%;
    animation: spin 1s linear infinite;
}

@keyframes spin {
    0% { transform: rotate(0deg); }
    100% { transform: rotate(360deg); }
}

.usage-tips h4 {
    color: var(--gray-600);
    margin-bottom: 1rem;
    font-size: 1rem;
}

.tip-box {
    background: white;
    padding: 1rem;
    border-radius: 8px;
    margin-bottom: 0.75rem;
    display: flex;
    align-items: flex-start;
    gap: 0.75rem;
}

.tip-box i {
    color: var(--primary-600);
    margin-top: 0.2rem;
}

.stats-content {
    padding: 2rem 0;
}

.stats-section {
    margin-bottom: 3rem;
}

.stats-section h3 {
    color: var(--gray-600);
    margin-bottom: 1.5rem;
    display: flex;
    align-items: center;
    gap: 0.5rem;
}

.decision-card {
    background: white;
    border-radius: 12px;
    padding: 2rem;
    box-shadow: 0 4px 15px rgba(0,0,0,0.1);
}

.decision-box {
    background: var(--gray-50);
    border-radius: 8px;
    padding: 1.5rem;
    text-align: center;
    max-width: 300px;
    border: 2px solid var(--gray-200);
}

.decision-box.primary {
    background: linear-gradient(135deg, var(--primary-600) 0%, var(--accent-600) 100%);
    color: white;
    border: none;
}

.decision-box.success {
    background: #d4edda;
    border-color: #c3e6cb;
    color: #155724;
}

.decision-box.warning {
    background: #fff3cd;
    border-color: #ffeaa7;
    color: #856404;
}

.decision-box.result {
    background: #e7f3ff;
    border-color: var(--primary-600);
    color: #004085;
}

.decision-arrow {
    font-size: 2rem;
    color: var(--primary-600);
    margin: 1rem 0;
    text-align: center;
}

.decision-branches {
    display: flex;
    gap: 4rem;
    justify-content: center;
}

.model-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(280px, 1fr));
    gap: 1.5rem;
}

.model-card {
    background: white;
    border-radius: 12px;
    padding: 1.5rem;
    box-shadow: 0 2px 10px rgba(0,0,0,0.08);
}

.model-card h4 {
    color: var(--gray-600);
    margin-bottom: 1rem;
    font-size: 1.1rem;
}

.model-card ul {
    list-style: none;
    padding-left: 0;
}

.model-card li {
    padding-left: 1.5rem;
    position: relative;
    margin-bottom: 0.5rem;
    line-height: 1.6;
}

.model-card li::before {
    content: "•";
    position: absolute;
    left: 0.5rem;
    color: var(--primary-600);
}

.formula-box {
    background: var(--primary-50);
    padding: 1rem;
    border-radius: 8px;
    text-align: center;
    font-family: 'Courier New', monospace;
}

.formula-note {
    font-size: 0.85rem;
    color: var(--gray-500);
    margin-top: 0.5rem;
}

.pros-cons {
    display: flex;
    flex-direction: column;
    gap: 1rem;
}

.pros,
.cons {
    padding: 0.75rem;
    border-radius: 6px;
}

.pros {
    background: #d4edda;
}

.cons {
    background: #f8d7da;
}

.pros strong {
    color: #155724;
}

.cons strong {
    color: #721c24;
}

.pros ul,
.cons ul {
    margin-top: 0.5rem;
}

.heterogeneity-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
    gap: 1.5rem;
}

.hetero-card {
    background: white;
    border-radius: 12px;
    padding: 1.5rem;
    box-shadow: 0 4px 15px rgba(0,0,0,0.1);
}

.hetero-icon {
    font-size: 2rem;
    color: var(--primary-600);
    margin-bottom: 1rem;
    text-align: center;
}

.hetero-card h4 {
    color: var(--gray-600);
    margin-bottom: 1rem;
    text-align: center;
}

.hetero-content {
    font-size: 0.95rem;
}

.interpretation {
    background: var(--gray-50);
    padding: 1rem;
    border-radius: 8px;
    margin-top: 1rem;
}

.interpretation h5 {
    color: var(--gray-600);
    margin-bottom: 0.5rem;
    font-size: 0.9rem;
}

.badge {
    display: inline-block;
    padding: 0.25rem 0.5rem;
    border-radius: 4px;
    font-size: 0.8rem;
    font-weight: bold;
    margin-right: 0.5rem;
}

.badge.low {
    background: #d4edda;
    color: #155724;
}

.badge.moderate {
    background: #fff3cd;
    color: #856404;
}

.badge.high {
    background: #f8d7da;
    color: #721c24;
}

.badge.very-high {
    background: #721c24;
    color: white;
}

.method-accordion {
    display: flex;
    flex-direction: column;
    gap: 1rem;
}

.method-item {
    background: white;
    border-radius: 12px;
    box-shadow: 0 2px 10px rgba(0,0,0,0.08);
    overflow: hidden;
}

.method-header {
    background: var(--gray-50);
    padding: 1.25rem;
    cursor: pointer;
    display: flex;
    justify-content: space-between;
    align-items: center;
    transition: background-color 0.3s ease;
}

.method-header:hover {
    background: var(--gray-200);
}

.method-header span {
    display: flex;
    align-items: center;
    gap: 0.75rem;
    font-weight: 600;
    color: var(--gray-600);
}

.method-content {
    padding: 1.5rem;
    display: none;
    background: white;
}

.method-content.active {
    display: block;
}

.method-content h5 {
    color: var(--primary-600);
    margin-bottom: 0.5rem;
    margin-top: 1rem;
}

.method-content h5:first-child {
    margin-top: 0;
}

.method-content ul {
    list-style: none;
    padding-left: 0;
}

.method-content li {
    padding-left: 1.5rem;
    position: relative;
    margin-bottom: 0.5rem;
}

.method-content li::before {
    content: "▸";
    position: absolute;
    left: 0;
    color: var(--primary-600);
}

.recommendation-table {
    overflow-x: auto;
    margin-top: 1rem;
}

.recommendation-table table {
    width: 100%;
    background: white;
    border-radius: 12px;
    overflow: hidden;
    box-shadow: 0 4px 15px rgba(0,0,0,0.1);
}

.recommendation-table th,
.recommendation-table td {
    padding: 1rem;
    text-align: left;
    border-bottom: 1px solid var(--gray-200);
}

.recommendation-table th {
    background: linear-gradient(135deg, var(--primary-600) 0%, var(--accent-600) 100%);
    color: white;
    font-weight: 600;
}

.recommendation-table tr:hover {
    background: var(--gray-50);
}

.recommendation-table tr:last-child td {
    border-bottom: none;
}

.outcome-methods {
    margin-top: 2rem;
    padding: 1.5rem;
    background: var(--gray-50);
    border-radius: 12px;
    border: 1px solid var(--gray-200);
}

.outcome-methods h4 {
    color: var(--gray-600);
    margin-bottom: 1.5rem;
    display: flex;
    align-items: center;
    gap: 0.5rem;
}

.outcome-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
    gap: 1.5rem;
}

.outcome-card {
    background: white;
    border-radius: 8px;
    overflow: hidden;
    box-shadow: 0 2px 8px rgba(0,0,0,0.08);
}

.outcome-header {
    background: linear-gradient(135deg, var(--primary-600) 0%, var(--accent-600) 100%);
    color: white;
    padding: 1rem;
}

.outcome-header h5 {
    margin: 0;
    display: flex;
    align-items: center;
    gap: 0.5rem;
}

.method-list {
    padding: 1rem;
}

.method-item-small {
    margin-bottom: 1rem;
    padding-bottom: 1rem;
    border-bottom: 1px solid #f1f1f1;
}

.method-item-small:last-child {
    border-bottom: none;
    margin-bottom: 0;
    padding-bottom: 0;
}

.method-item-small strong {
    color: var(--gray-600);
    display: block;
    margin-bottom: 0.25rem;
}

.method-item-small p {
    color: var(--gray-500);
    font-size: 0.9rem;
    line-height: 1.4;
    margin-bottom: 0.25rem;
}

.formula-small {
    font-family: 'Courier New', monospace;
    background: var(--primary-50);
    padding: 0.25rem 0.5rem;
    border-radius: 4px;
    font-size: 0.85rem;
    color: var(--gray-600);
    display: inline-block;
}

.tau-methods {
    margin-top: 2rem;
    padding: 1.5rem;
    background: #fff3e0;
    border-radius: 12px;
    border: 1px solid #ffcc80;
}

.tau-methods h4 {
    color: var(--gray-600);
    margin-bottom: 1.5rem;
    display: flex;
    align-items: center;
    gap: 0.5rem;
}

.tau-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(280px, 1fr));
    gap: 1.5rem;
}

.tau-method-card {
    background: white;
    border-radius: 8px;
    padding: 1.5rem;
    box-shadow: 0 2px 8px rgba(0,0,0,0.08);
}

.tau-method-card h5 {
    color: #e65100;
    margin-bottom: 1rem;
    font-size: 1.1rem;
}

.tau-method-card ul {
    list-style: none;
    padding-left: 0;
}

.tau-method-card li {
    padding-left: 1.5rem;
    position: relative;
    margin-bottom: 0.5rem;
    line-height: 1.6;
    font-size: 0.9rem;
}

.tau-method-card li::before {
    content: "•";
    position: absolute;
    left: 0.5rem;
    color: #ff9800;
}

.checklist-container {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(250px, 1fr));
    gap: 2rem;
    background: white;
    padding: 2rem;
    border-radius: 12px;
    box-shadow: 0 4px 15px rgba(0,0,0,0.1);
}

.checklist-column h4 {
    color: var(--primary-600);
    margin-bottom: 1rem;
    padding-bottom: 0.5rem;
    border-bottom: 2px solid var(--gray-200);
}

.checklist-item {
    display: flex;
    align-items: center;
    margin-bottom: 0.75rem;
    cursor: pointer;
    padding: 0.5rem;
    border-radius: 6px;
    transition: background-color 0.3s ease;
}

.checklist-item:hover {
    background: var(--gray-50);
}

.checklist-item input[type="checkbox"] {
    width: 1.2rem;
    height: 1.2rem;
    margin-right: 0.75rem;
    cursor: pointer;
}

.checklist-item span {
    color: var(--gray-600);
    font-size: 0.95rem;
}

.checklist-item input[type="checkbox"]:checked + span {
    color: var(--success);
    text-decoration: line-through;
}

@media (max-width: 768px) {
    .decision-branches {
        flex-direction: column;
        gap: 2rem;
    }

    .model-grid {
        grid-template-columns: 1fr;
    }

    .heterogeneity-grid {
        grid-template-columns: 1fr;
    }

    .checklist-container {
        grid-template-columns: 1fr;
    }

    .recommendation-table {
        font-size: 0.85rem;
    }

    .recommendation-table th,
    .recommendation-table td {
        padding: 0.5rem;
    }
}

.hidden {
    display: none !important;
}

.visible {
    display: block !important;
}

.heterogeneity-guide {
    display: flex;
    flex-direction: column;
    gap: 2rem;
}

.heterogeneity-card {
    background: white;
    border-radius: 12px;
    padding: 2rem;
    box-shadow: 0 4px 12px rgba(0,0,0,0.1);
    border: 1px solid var(--gray-200);
}

.heterogeneity-card h4 {
    color: var(--gray-600);
    margin-bottom: 1.5rem;
    display: flex;
    align-items: center;
    gap: 0.5rem;
}

.i-squared-scale {
    display: flex;
    flex-direction: column;
    gap: 1rem;
    margin-bottom: 2rem;
}

.scale-item {
    display: flex;
    align-items: center;
    padding: 1rem;
    border-radius: 8px;
    border-left: 4px solid;
    background: var(--gray-50);
    transition: all 0.3s ease;
}

.scale-item:hover {
    transform: translateX(5px);
    box-shadow: 0 2px 8px rgba(0,0,0,0.1);
}

.scale-item.low {
    border-left-color: var(--success);
    background: #f0fff4;
}

.scale-item.moderate {
    border-left-color: var(--warning);
    background: #fffbf0;
}

.scale-item.substantial {
    border-left-color: #fd7e14;
    background: #fff5f0;
}

.scale-item.considerable {
    border-left-color: #dc3545;
    background: #fff0f0;
}

.scale-range {
    font-weight: bold;
    font-size: 1.1rem;
    color: var(--gray-600);
    min-width: 100px;
}

.scale-label {
    font-weight: 600;
    margin: 0 1rem;
    min-width: 120px;
}

.scale-note {
    color: var(--gray-500);
    font-size: 0.9rem;
    flex: 1;
}

.cochrane-note {
    background: #e3f2fd;
    border: 1px solid #bbdefb;
    border-radius: 8px;
    padding: 1.5rem;
    margin-top: 1.5rem;
}

.cochrane-note p {
    margin-bottom: 1rem;
    color: #1565c0;
}

.cochrane-note ul {
    list-style: none;
    padding-left: 0;
}

.cochrane-note li {
    position: relative;
    padding-left: 1.5rem;
    margin-bottom: 0.5rem;
    color: var(--gray-600);
}

.cochrane-note li::before {
    content: "▸";
    position: absolute;
    left: 0;
    color: #1565c0;
    font-weight: bold;
}

.stats-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(250px, 1fr));
    gap: 1.5rem;
}

.stat-item {
    display: flex;
    align-items: flex-start;
    gap: 1rem;
    padding: 1.5rem;
    background: var(--gray-50);
    border-radius: 8px;
    border: 1px solid var(--gray-200);
}

.stat-symbol {
    font-size: 2rem;
    font-weight: bold;
    color: var(--primary-600);
    font-family: 'Times New Roman', serif;
    min-width: 50px;
    text-align: center;
    background: var(--primary-50);
    padding: 0.5rem;
    border-radius: 50%;
}

.stat-desc {
    flex: 1;
    line-height: 1.6;
    font-size: 0.9rem;
    color: var(--gray-600);
}

.decision-card.enhanced {
    background: white;
    padding: 2rem;
    border-radius: 16px;
    color: var(--gray-800);
    box-shadow: 0 8px 24px rgba(0, 0, 0, 0.1);
    border: 1px solid var(--gray-200);
}

.decision-flow-enhanced {
    display: flex;
    flex-direction: column;
    gap: 2rem;
}

.decision-step {
    display: flex;
    justify-content: center;
}

.decision-branches-enhanced {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(280px, 1fr));
    gap: 2rem;
    margin-top: 1rem;
}

.branch-column {
    display: flex;
    flex-direction: column;
    align-items: center;
    gap: 1rem;
}

.decision-box {
    background: rgba(255, 255, 255, 0.95);
    color: var(--gray-600);
    padding: 1.5rem;
    border-radius: 12px;
    box-shadow: 0 4px 12px rgba(0, 0, 0, 0.1);
    width: 100%;
    text-align: center;
    transition: transform 0.3s ease, box-shadow 0.3s ease;
}

.decision-box:hover {
    transform: translateY(-2px);
    box-shadow: 0 6px 20px rgba(0, 0, 0, 0.15);
}

.decision-box h4 {
    margin-bottom: 1rem;
    color: var(--gray-600);
    font-weight: 600;
}

.decision-box.primary h4 {
    color: #fff;
}

.decision-box ul {
    list-style: none;
    padding: 0;
    text-align: left;
}

.decision-box li {
    position: relative;
    padding-left: 1.2rem;
    margin-bottom: 0.5rem;
    font-size: 0.9rem;
}

.decision-box li::before {
    content: "•";
    position: absolute;
    left: 0;
    font-weight: bold;
}

.decision-box.success li::before {
    color: var(--success);
}

.decision-box.warning li::before {
    color: var(--warning);
}

.decision-box.danger li::before {
    color: #dc3545;
}

.decision-box.result {
    font-weight: bold;
    border: 2px solid;
}

.decision-box.result.success {
    border-color: var(--success);
    background: linear-gradient(135deg, #d4edda, #c3e6cb);
}

.decision-box.result.warning {
    border-color: var(--warning);
    background: linear-gradient(135deg, #fff3cd, #ffeaa7);
}

.decision-box.result.danger {
    border-color: #dc3545;
    background: linear-gradient(135deg, #f8d7da, #f5c6cb);
}

.grade-overview {
    display: flex;
    flex-direction: column;
    gap: 3rem;
}

.grade-intro {
    background: var(--gray-50);
    padding: 2rem;
    border-radius: 12px;
    border-left: 4px solid var(--primary-600);
}

.grade-intro p {
    font-size: 1.1rem;
    line-height: 1.6;
    color: var(--gray-600);
    margin: 0;
}

.grade-levels {
    background: white;
    border-radius: 12px;
    padding: 2rem;
    box-shadow: 0 4px 12px rgba(0,0,0,0.1);
}

.grade-levels h4 {
    color: var(--gray-600);
    margin-bottom: 2rem;
    display: flex;
    align-items: center;
    gap: 0.5rem;
}

.grade-scale {
    display: flex;
    flex-direction: column;
    gap: 1.5rem;
}

.grade-item {
    display: flex;
    align-items: center;
    padding: 1.5rem;
    border-radius: 12px;
    gap: 2rem;
    transition: transform 0.3s ease, box-shadow 0.3s ease;
}

.grade-item:hover {
    transform: translateX(5px);
    box-shadow: 0 4px 16px rgba(0,0,0,0.1);
}

.grade-item.very-high {
    background: linear-gradient(135deg, #d4edda, #c3e6cb);
    border: 2px solid var(--success);
}

.grade-item.high {
    background: linear-gradient(135deg, #cce5ff, #b3d9ff);
    border: 2px solid #007bff;
}

.grade-item.moderate {
    background: linear-gradient(135deg, #fff3cd, #ffeaa7);
    border: 2px solid var(--warning);
}

.grade-item.low {
    background: linear-gradient(135deg, #f8d7da, #f5c6cb);
    border: 2px solid #dc3545;
}

.grade-circle {
    font-size: 2rem;
    font-weight: bold;
    color: var(--gray-600);
    min-width: 120px;
    text-align: center;
    background: white;
    padding: 1rem;
    border-radius: 50%;
    box-shadow: 0 2px 8px rgba(0,0,0,0.1);
}

.grade-content {
    flex: 1;
}

.grade-content h5 {
    color: var(--gray-600);
    margin-bottom: 0.5rem;
    font-size: 1.2rem;
}

.grade-content p {
    color: var(--gray-600);
    margin-bottom: 0.5rem;
    font-weight: 500;
}

.grade-note {
    font-size: 0.9rem;
    color: var(--gray-500);
    font-style: italic;
}

.grade-factors {
    background: white;
    border-radius: 12px;
    padding: 2rem;
    box-shadow: 0 4px 12px rgba(0,0,0,0.1);
}

.grade-factors h4 {
    color: var(--gray-600);
    margin-bottom: 2rem;
    display: flex;
    align-items: center;
    gap: 0.5rem;
}

.factors-grid {
    display: grid;
    grid-template-columns: 2fr 1fr;
    gap: 2rem;
}

.factor-group {
    padding: 1.5rem;
    border-radius: 12px;
    border: 2px solid;
}

.factor-group.downgrade {
    border-color: #dc3545;
    background: #fff5f5;
}

.factor-group.upgrade {
    border-color: var(--success);
    background: #f0fff4;
}

.factor-group h5 {
    color: var(--gray-600);
    margin-bottom: 1.5rem;
    display: flex;
    align-items: center;
    gap: 0.5rem;
    font-size: 1.1rem;
}

.factor-list {
    display: flex;
    flex-direction: column;
    gap: 1.5rem;
}

.factor-item {
    display: flex;
    gap: 1rem;
    background: white;
    padding: 1.5rem;
    border-radius: 8px;
    box-shadow: 0 2px 8px rgba(0,0,0,0.05);
}

.factor-icon {
    font-size: 1.5rem;
    color: var(--primary-600);
    min-width: 40px;
    text-align: center;
}

.factor-content {
    flex: 1;
}

.factor-content h6 {
    color: var(--gray-600);
    margin-bottom: 0.75rem;
    font-size: 1rem;
    font-weight: 600;
}

.factor-content ul {
    list-style: none;
    padding: 0;
    margin: 0;
}

.factor-content li {
    position: relative;
    padding-left: 1.2rem;
    margin-bottom: 0.5rem;
    font-size: 0.9rem;
    color: var(--gray-500);
}

.factor-content li::before {
    content: "▸";
    position: absolute;
    left: 0;
    color: var(--primary-600);
    font-weight: bold;
}

.grade-decision-tree {
    background: white;
    border-radius: 12px;
    padding: 2rem;
    box-shadow: 0 4px 12px rgba(0,0,0,0.1);
}

.grade-decision-tree h4 {
    color: var(--gray-600);
    margin-bottom: 2rem;
    display: flex;
    align-items: center;
    gap: 0.5rem;
}

.decision-tree {
    display: flex;
    flex-direction: column;
    align-items: center;
    gap: 1.5rem;
}

.tree-step {
    width: 100%;
    display: flex;
    justify-content: center;
}

.tree-box {
    background: var(--gray-50);
    padding: 1.5rem;
    border-radius: 12px;
    border: 2px solid var(--gray-200);
    min-width: 300px;
    text-align: center;
}

.tree-box.start {
    background: linear-gradient(135deg, var(--primary-600), var(--accent-600));
    color: white;
    border-color: var(--primary-600);
}

.tree-box.evaluation {
    background: linear-gradient(135deg, var(--warning), #ffb300);
    color: var(--gray-600);
    border-color: var(--warning);
}

.tree-box.upgrade {
    background: linear-gradient(135deg, var(--success), #20c997);
    color: white;
    border-color: var(--success);
}

.tree-box.final {
    background: linear-gradient(135deg, #dc3545, #e83e8c);
    color: white;
    border-color: #dc3545;
}

.tree-box h5 {
    margin-bottom: 1rem;
    font-weight: 600;
}

.tree-box p {
    margin: 0;
    font-size: 0.9rem;
}

.tree-branches {
    display: flex;
    flex-direction: column;
    gap: 1rem;
    margin-top: 1rem;
}

.branch {
    display: flex;
    justify-content: space-between;
    align-items: center;
    padding: 0.75rem;
    background: rgba(255,255,255,0.9);
    border-radius: 8px;
    color: var(--gray-600);
}

.initial-grade {
    font-weight: bold;
    font-size: 1.1rem;
}

.initial-grade.high {
    color: var(--success);
}

.initial-grade.low {
    color: #dc3545;
}

.tree-arrow {
    font-size: 2rem;
    color: var(--primary-600);
    font-weight: bold;
}

.effect-measures-guide {
    display: flex;
    flex-direction: column;
    gap: 3rem;
}

.cochrane-principles {
    background: white;
    border-radius: 12px;
    padding: 2rem;
    box-shadow: 0 4px 12px rgba(0,0,0,0.1);
}

.cochrane-principles h4 {
    color: var(--gray-600);
    margin-bottom: 2rem;
    display: flex;
    align-items: center;
    gap: 0.5rem;
}

.principles-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
    gap: 2rem;
}

.principle-card {
    background: var(--gray-50);
    border-radius: 12px;
    padding: 2rem;
    text-align: center;
    border: 2px solid var(--gray-200);
    transition: transform 0.3s ease, box-shadow 0.3s ease;
}

.principle-card:hover {
    transform: translateY(-5px);
    box-shadow: 0 8px 24px rgba(0,0,0,0.15);
    border-color: var(--primary-600);
}

.principle-icon {
    font-size: 3rem;
    color: var(--primary-600);
    margin-bottom: 1rem;
}

.principle-card h5 {
    color: var(--gray-600);
    margin-bottom: 1rem;
    font-size: 1.3rem;
}

.principle-card p {
    color: var(--gray-500);
    margin-bottom: 1.5rem;
    font-style: italic;
}

.principle-card ul {
    list-style: none;
    padding: 0;
    text-align: left;
}

.principle-card li {
    position: relative;
    padding-left: 1.2rem;
    margin-bottom: 0.5rem;
    color: var(--gray-600);
    font-size: 0.9rem;
}

.principle-card li::before {
    content: "▸";
    position: absolute;
    left: 0;
    color: var(--primary-600);
    font-weight: bold;
}

.continuous-effects {
    background: white;
    border-radius: 12px;
    padding: 2rem;
    box-shadow: 0 4px 12px rgba(0,0,0,0.1);
}

.continuous-effects h4 {
    color: var(--gray-600);
    margin-bottom: 2rem;
    display: flex;
    align-items: center;
    gap: 0.5rem;
}

.effect-comparison {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(400px, 1fr));
    gap: 2rem;
}

.effect-measure-card {
    border-radius: 12px;
    padding: 2rem;
    border: 2px solid;
    transition: transform 0.3s ease, box-shadow 0.3s ease;
}

.effect-measure-card:hover {
    transform: translateY(-3px);
    box-shadow: 0 6px 20px rgba(0,0,0,0.1);
}

.effect-measure-card.md-card {
    border-color: var(--success);
    background: linear-gradient(135deg, #f0fff4, #d4edda);
}

.effect-measure-card.smd-card {
    border-color: #007bff;
    background: linear-gradient(135deg, #f0f8ff, #cce5ff);
}

.effect-header {
    display: flex;
    justify-content: space-between;
    align-items: center;
    margin-bottom: 1.5rem;
    padding-bottom: 1rem;
    border-bottom: 2px solid rgba(0,0,0,0.1);
}

.effect-header h5 {
    color: var(--gray-600);
    font-size: 1.2rem;
    margin: 0;
}

.effect-symbol {
    font-family: 'Times New Roman', serif;
    font-size: 1.1rem;
    font-weight: bold;
    color: var(--gray-600);
    background: white;
    padding: 0.5rem 1rem;
    border-radius: 8px;
    box-shadow: 0 2px 4px rgba(0,0,0,0.1);
}

.effect-details {
    display: flex;
    flex-direction: column;
    gap: 1.5rem;
}

.advantages,
.limitations {
    background: white;
    padding: 1.5rem;
    border-radius: 8px;
    box-shadow: 0 2px 8px rgba(0,0,0,0.05);
}

.advantages h6 {
    color: var(--success);
    margin-bottom: 1rem;
    display: flex;
    align-items: center;
    gap: 0.5rem;
}

.limitations h6 {
    color: #dc3545;
    margin-bottom: 1rem;
    display: flex;
    align-items: center;
    gap: 0.5rem;
}

.effect-details ul {
    list-style: none;
    padding: 0;
    margin: 0;
}

.effect-details li {
    position: relative;
    padding-left: 1.2rem;
    margin-bottom: 0.5rem;
    color: var(--gray-600);
    font-size: 0.9rem;
}

.effect-details li::before {
    content: "•";
    position: absolute;
    left: 0;
    color: var(--primary-600);
    font-weight: bold;
}

.interpretation-guide {
    background: #fff3cd;
    border: 1px solid #ffeaa7;
    border-radius: 8px;
    padding: 1.5rem;
}

.interpretation-guide h6 {
    color: var(--gray-600);
    margin-bottom: 1rem;
}

.cohen-scale {
    display: flex;
    gap: 1rem;
    flex-wrap: wrap;
}

.scale-item {
    background: white;
    padding: 0.5rem 1rem;
    border-radius: 20px;
    border: 2px solid;
    font-size: 0.9rem;
    font-weight: 600;
}

.scale-item.small {
    border-color: var(--success);
    color: var(--success);
}

.scale-item.medium {
    border-color: var(--warning);
    color: var(--warning);
}

.scale-item.large {
    border-color: #dc3545;
    color: #dc3545;
}

.binary-effects {
    background: white;
    border-radius: 12px;
    padding: 2rem;
    box-shadow: 0 4px 12px rgba(0,0,0,0.1);
}

.binary-effects h4 {
    color: var(--gray-600);
    margin-bottom: 2rem;
    display: flex;
    align-items: center;
    gap: 0.5rem;
}

.binary-measures-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(320px, 1fr));
    gap: 2rem;
}

.binary-measure-card {
    border-radius: 12px;
    padding: 2rem;
    border: 2px solid;
    transition: transform 0.3s ease, box-shadow 0.3s ease;
}

.binary-measure-card:hover {
    transform: translateY(-3px);
    box-shadow: 0 6px 20px rgba(0,0,0,0.1);
}

.binary-measure-card.or-card {
    border-color: #e83e8c;
    background: linear-gradient(135deg, #fff0f6, #f8d7da);
}

.binary-measure-card.rr-card {
    border-color: #fd7e14;
    background: linear-gradient(135deg, #fff8f0, #ffe4cc);
}

.binary-measure-card.rd-card {
    border-color: #6610f2;
    background: linear-gradient(135deg, #f8f0ff, #e2d9f3);
}

.measure-header {
    text-align: center;
    margin-bottom: 1.5rem;
    padding-bottom: 1rem;
    border-bottom: 2px solid rgba(0,0,0,0.1);
}

.measure-header h5 {
    color: var(--gray-600);
    margin-bottom: 0.5rem;
    font-size: 1.2rem;
}

.measure-formula {
    font-family: 'Times New Roman', serif;
    font-size: 1rem;
    font-weight: bold;
    background: white;
    padding: 0.5rem 1rem;
    border-radius: 8px;
    display: inline-block;
    box-shadow: 0 2px 4px rgba(0,0,0,0.1);
}

.measure-properties {
    display: flex;
    flex-direction: column;
    gap: 1rem;
}

.property-item {
    background: white;
    padding: 1rem;
    border-radius: 8px;
    font-size: 0.9rem;
    line-height: 1.5;
    box-shadow: 0 2px 8px rgba(0,0,0,0.05);
}

.property-item strong {
    color: var(--primary-600);
}

.survival-effects {
    background: white;
    border-radius: 12px;
    padding: 2rem;
    box-shadow: 0 4px 12px rgba(0,0,0,0.1);
}

.survival-effects h4 {
    color: var(--gray-600);
    margin-bottom: 2rem;
    display: flex;
    align-items: center;
    gap: 0.5rem;
}

.survival-measure-card {
    border: 2px solid #20c997;
    background: linear-gradient(135deg, #f0fff8, #d1ecf1);
    border-radius: 12px;
    padding: 2rem;
}

.survival-header {
    text-align: center;
    margin-bottom: 2rem;
    padding-bottom: 1rem;
    border-bottom: 2px solid rgba(0,0,0,0.1);
}

.survival-header h5 {
    color: var(--gray-600);
    margin-bottom: 0.5rem;
    font-size: 1.3rem;
}

.survival-formula {
    font-family: 'Times New Roman', serif;
    font-size: 1.2rem;
    font-weight: bold;
    background: white;
    padding: 0.75rem 1.5rem;
    border-radius: 8px;
    display: inline-block;
    box-shadow: 0 2px 4px rgba(0,0,0,0.1);
}

.survival-details {
    display: grid;
    grid-template-columns: 2fr 1fr;
    gap: 2rem;
}

.survival-properties,
.survival-interpretation {
    background: white;
    padding: 1.5rem;
    border-radius: 8px;
    box-shadow: 0 2px 8px rgba(0,0,0,0.05);
}

.survival-properties h6,
.survival-interpretation h6 {
    color: var(--gray-600);
    margin-bottom: 1rem;
}

.survival-properties ul {
    list-style: none;
    padding: 0;
}

.survival-properties li {
    position: relative;
    padding-left: 1.2rem;
    margin-bottom: 1rem;
    color: var(--gray-600);
    font-size: 0.9rem;
    line-height: 1.5;
}

.survival-properties li::before {
    content: "▸";
    position: absolute;
    left: 0;
    color: #20c997;
    font-weight: bold;
}

.hr-examples {
    display: flex;
    flex-direction: column;
    gap: 1rem;
}

.hr-example {
    display: flex;
    justify-content: space-between;
    align-items: center;
    padding: 1rem;
    background: var(--gray-50);
    border-radius: 8px;
    border: 1px solid var(--gray-200);
}

.hr-value {
    font-weight: bold;
    color: var(--gray-600);
}

.hr-meaning {
    color: var(--gray-500);
    font-size: 0.9rem;
}

.conversion-guide {
    background: white;
    border-radius: 12px;
    padding: 2rem;
    box-shadow: 0 4px 12px rgba(0,0,0,0.1);
}

.conversion-guide h4 {
    color: var(--gray-600);
    margin-bottom: 2rem;
    display: flex;
    align-items: center;
    gap: 0.5rem;
}

.conversion-scenarios {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
    gap: 2rem;
}

.scenario-card {
    background: var(--gray-50);
    border: 2px solid var(--gray-200);
    border-radius: 12px;
    padding: 2rem;
    text-align: center;
    transition: transform 0.3s ease, box-shadow 0.3s ease;
}

.scenario-card:hover {
    transform: translateY(-3px);
    box-shadow: 0 6px 20px rgba(0,0,0,0.1);
    border-color: var(--primary-600);
}

.scenario-card h5 {
    color: var(--gray-600);
    margin-bottom: 1rem;
    font-size: 1.1rem;
}

.conversion-formula {
    background: var(--gray-600);
    color: white;
    padding: 1rem;
    border-radius: 8px;
    margin: 1rem 0;
    font-family: 'Courier New', monospace;
}

.conversion-formula code {
    background: none;
    color: white;
    font-size: 1rem;
}

.scenario-card p {
    color: var(--gray-500);
    font-size: 0.9rem;
    line-height: 1.5;
    margin: 0;
}

.grade-content {
    display: flex;
    flex-direction: column;
    gap: 3rem;
}

.grade-section {
    background: white;
    border-radius: 12px;
    padding: 2rem;
    box-shadow: 0 4px 12px rgba(0,0,0,0.1);
    border: 1px solid var(--gray-200);
}

.grade-section h3 {
    display: flex;
    align-items: center;
    gap: 0.75rem;
    color: var(--gray-700);
    margin-bottom: 1.5rem;
    padding-bottom: 1rem;
    border-bottom: 2px solid var(--gray-200);
}

.grade-section h3 i {
    color: var(--primary-600);
}

.grade-intro .intro-card {
    background: linear-gradient(135deg, #f0fdfa, #e0f7fa);
    border: 1px solid var(--primary-200);
}

.outcome-importance {
    display: flex;
    flex-direction: column;
    gap: 2rem;
}

.outcome-intro {
    background: linear-gradient(135deg, #e8f4fd, #d1e9ff);
    padding: 1.25rem 1.5rem;
    border-radius: 10px;
    border-left: 4px solid #007bff;
}

.outcome-intro p {
    margin: 0;
    color: var(--gray-700);
    line-height: 1.6;
}

.rating-scale-section h4,
.patient-outcomes-section h4,
.surrogate-outcomes-section h4,
.rating-process-section h4 {
    display: flex;
    align-items: center;
    gap: 0.5rem;
    color: var(--gray-700);
    margin-bottom: 1rem;
    font-size: 1.1rem;
}

.rating-scale-section h4 i,
.patient-outcomes-section h4 i,
.surrogate-outcomes-section h4 i,
.rating-process-section h4 i {
    color: var(--primary-600);
}

.rating-scale-section > p {
    margin-bottom: 1.25rem;
    color: var(--gray-600);
}

.importance-scale {
    display: flex;
    flex-direction: column;
    gap: 1rem;
}

.scale-category {
    border-radius: 12px;
    overflow: hidden;
    border: 2px solid;
}

.scale-category.critical {
    border-color: #dc3545;
}

.scale-category.important {
    border-color: #ffc107;
}

.scale-category.limited {
    border-color: #6c757d;
}

.scale-header {
    padding: 0.75rem 1.25rem;
    display: flex;
    align-items: center;
    gap: 1rem;
}

.scale-category.critical .scale-header {
    background: linear-gradient(135deg, #dc3545, #c82333);
    color: white;
}

.scale-category.important .scale-header {
    background: linear-gradient(135deg, #ffc107, #e0a800);
    color: #333;
}

.scale-category.limited .scale-header {
    background: linear-gradient(135deg, #6c757d, #5a6268);
    color: white;
}

.scale-range {
    font-weight: bold;
    font-size: 1.1rem;
    padding: 0.25rem 0.75rem;
    background: rgba(255,255,255,0.2);
    border-radius: 6px;
}

.scale-label {
    font-weight: 600;
    font-size: 1rem;
}

.scale-content {
    padding: 1.25rem;
    background: white;
}

.scale-content h5 {
    margin: 0 0 0.5rem 0;
    color: var(--gray-700);
    font-size: 0.95rem;
}

.scale-content > p {
    margin: 0;
    color: var(--gray-600);
    font-size: 0.9rem;
    line-height: 1.5;
}

.scale-note {
    margin-top: 1rem;
    padding: 0.75rem 1rem;
    background: #fff3cd;
    border-radius: 8px;
    display: flex;
    align-items: flex-start;
    gap: 0.75rem;
    font-size: 0.85rem;
    color: #856404;
}

.scale-note i {
    margin-top: 2px;
    color: #d39e00;
}

.outcomes-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(280px, 1fr));
    gap: 1.5rem;
    margin-bottom: 1rem;
}

.outcome-type {
    border-radius: 12px;
    padding: 1.5rem;
    display: flex;
    gap: 1rem;
    align-items: flex-start;
}

.outcome-type.desired {
    background: linear-gradient(135deg, #d4edda, #c3e6cb);
    border: 1px solid #28a745;
}

.outcome-type.undesired {
    background: linear-gradient(135deg, #f8d7da, #f5c6cb);
    border: 1px solid #dc3545;
}

.outcome-icon {
    width: 48px;
    height: 48px;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    flex-shrink: 0;
}

.outcome-type.desired .outcome-icon {
    background: #28a745;
    color: white;
    font-size: 1.5rem;
}

.outcome-type.undesired .outcome-icon {
    background: #dc3545;
    color: white;
    font-size: 1.5rem;
}

.outcome-content h5 {
    margin: 0 0 0.75rem 0;
    font-size: 1rem;
}

.outcome-type.desired .outcome-content h5 {
    color: #155724;
}

.outcome-type.undesired .outcome-content h5 {
    color: #721c24;
}

.outcome-content ul {
    margin: 0;
    padding-left: 1.25rem;
}

.outcome-content li {
    margin-bottom: 0.35rem;
    font-size: 0.9rem;
}

.outcome-type.desired .outcome-content li {
    color: #155724;
}

.outcome-type.undesired .outcome-content li {
    color: #721c24;
}

.outcome-tip {
    background: #e7f3ff;
    border-radius: 8px;
    padding: 1rem 1.25rem;
    display: flex;
    align-items: flex-start;
    gap: 0.75rem;
    font-size: 0.9rem;
    color: #004085;
    border-left: 3px solid #007bff;
}

.outcome-tip i {
    color: #007bff;
    margin-top: 2px;
}

.surrogate-comparison {
    display: grid;
    grid-template-columns: 1fr auto 1fr;
    gap: 1rem;
    align-items: stretch;
    margin-bottom: 1.25rem;
}

.surrogate-item {
    background: white;
    border-radius: 12px;
    padding: 1.5rem;
    border: 2px solid;
    position: relative;
}

.surrogate-item.clinical {
    border-color: #28a745;
}

.surrogate-item.surrogate {
    border-color: #ffc107;
}

.surrogate-item h5 {
    display: flex;
    align-items: center;
    gap: 0.5rem;
    margin: 0 0 0.5rem 0;
    font-size: 1rem;
}

.surrogate-item.clinical h5 {
    color: #28a745;
}

.surrogate-item.surrogate h5 {
    color: #d39e00;
}

.surrogate-item > p {
    margin: 0 0 1rem 0;
    color: var(--gray-600);
    font-size: 0.9rem;
}

.example-box {
    background: var(--gray-50);
    padding: 1rem;
    border-radius: 8px;
    margin-bottom: 1rem;
}

.example-box strong {
    display: block;
    margin-bottom: 0.5rem;
    color: var(--gray-700);
    font-size: 0.85rem;
}

.example-box ul {
    margin: 0;
    padding-left: 1.25rem;
}

.example-box li {
    font-size: 0.85rem;
    color: var(--gray-600);
    margin-bottom: 0.25rem;
}

.preference-badge {
    display: inline-block;
    padding: 0.35rem 0.75rem;
    border-radius: 20px;
    font-size: 0.8rem;
    font-weight: 600;
}

.preference-badge.preferred {
    background: #d4edda;
    color: #155724;
}

.preference-badge.caution {
    background: #fff3cd;
    color: #856404;
}

.surrogate-arrow {
    display: flex;
    align-items: center;
    justify-content: center;
    color: var(--gray-400);
    font-size: 1.5rem;
}

.surrogate-warning {
    background: #fff3cd;
    border-radius: 10px;
    padding: 1rem 1.25rem;
    display: flex;
    align-items: flex-start;
    gap: 1rem;
    border: 1px solid #ffc107;
}

.surrogate-warning > i {
    color: #d39e00;
    font-size: 1.25rem;
    margin-top: 2px;
}

.surrogate-warning strong {
    display: block;
    margin-bottom: 0.35rem;
    color: #856404;
}

.surrogate-warning p {
    margin: 0;
    color: #856404;
    font-size: 0.9rem;
    line-height: 1.5;
}

.process-steps {
    display: flex;
    flex-direction: column;
    gap: 1rem;
}

.process-step {
    display: flex;
    gap: 1rem;
    align-items: flex-start;
    background: var(--gray-50);
    padding: 1.25rem;
    border-radius: 10px;
    border: 1px solid var(--gray-200);
}

.process-number {
    width: 32px;
    height: 32px;
    border-radius: 50%;
    background: var(--primary-600);
    color: white;
    display: flex;
    align-items: center;
    justify-content: center;
    font-weight: bold;
    font-size: 0.9rem;
    flex-shrink: 0;
}

.process-content strong {
    display: block;
    margin-bottom: 0.35rem;
    color: var(--gray-700);
}

.process-content p {
    margin: 0;
    color: var(--gray-600);
    font-size: 0.9rem;
    line-height: 1.5;
}

@media (max-width: 768px) {
    .surrogate-comparison {
        grid-template-columns: 1fr;
    }

    .surrogate-arrow {
        transform: rotate(90deg);
        padding: 0.5rem 0;
    }

    .outcomes-grid {
        grid-template-columns: 1fr;
    }

    .process-step {
        flex-direction: column;
    }
}

.evidence-levels {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(280px, 1fr));
    gap: 1.5rem;
}

.level-card {
    border-radius: 12px;
    overflow: hidden;
    border: 2px solid;
    transition: transform 0.3s ease, box-shadow 0.3s ease;
}

.level-card:hover {
    transform: translateY(-5px);
    box-shadow: 0 8px 24px rgba(0,0,0,0.15);
}

.level-header {
    padding: 1rem 1.5rem;
    display: flex;
    justify-content: space-between;
    align-items: center;
}

.level-icon {
    display: flex;
    gap: 0.25rem;
}

.level-icon i {
    font-size: 0.9rem;
}

.level-badge {
    font-size: 1.1rem;
    font-weight: bold;
    letter-spacing: 1px;
}

.level-content {
    padding: 1.5rem;
    background: white;
}

.level-content h4 {
    margin-bottom: 0.75rem;
    font-size: 1.15rem;
}

.level-meaning {
    font-weight: 500;
    margin-bottom: 1rem;
    line-height: 1.5;
}

.level-implication {
    font-size: 0.9rem;
    color: var(--gray-600);
    margin-bottom: 0.75rem;
}

.level-start {
    font-size: 0.85rem;
    color: var(--gray-500);
    padding-top: 0.75rem;
    border-top: 1px dashed var(--gray-300);
}

.level-card.level-high {
    border-color: #28a745;
}

.level-card.level-high .level-header {
    background: linear-gradient(135deg, #28a745, #20c997);
    color: white;
}

.level-card.level-high .level-content h4 {
    color: #28a745;
}

.level-card.level-moderate {
    border-color: #17a2b8;
}

.level-card.level-moderate .level-header {
    background: linear-gradient(135deg, #17a2b8, #20c997);
    color: white;
}

.level-card.level-moderate .level-content h4 {
    color: #17a2b8;
}

.level-card.level-low {
    border-color: #ffc107;
}

.level-card.level-low .level-header {
    background: linear-gradient(135deg, #ffc107, #fd7e14);
    color: #333;
}

.level-card.level-low .level-content h4 {
    color: #d39e00;
}

.level-card.level-very-low {
    border-color: #dc3545;
}

.level-card.level-very-low .level-header {
    background: linear-gradient(135deg, #dc3545, #e83e8c);
    color: white;
}

.level-card.level-very-low .level-content h4 {
    color: #dc3545;
}

.grade-flow {
    display: flex;
    flex-direction: column;
    align-items: center;
    gap: 0.5rem;
}

.flow-step {
    display: flex;
    gap: 1.5rem;
    align-items: flex-start;
    background: var(--gray-50);
    padding: 1.5rem;
    border-radius: 12px;
    width: 100%;
    max-width: 600px;
    border: 1px solid var(--gray-200);
}

.flow-step.final {
    background: linear-gradient(135deg, var(--primary-50), var(--primary-100));
    border-color: var(--primary-300);
}

.step-number {
    width: 40px;
    height: 40px;
    border-radius: 50%;
    background: var(--primary-600);
    color: white;
    display: flex;
    align-items: center;
    justify-content: center;
    font-weight: bold;
    font-size: 1.2rem;
    flex-shrink: 0;
}

.step-content h4 {
    margin-bottom: 0.5rem;
    color: var(--gray-700);
}

.step-content p {
    margin-bottom: 0.5rem;
    color: var(--gray-600);
    font-size: 0.9rem;
}

.step-content ul {
    margin: 0;
    padding-left: 1.25rem;
}

.step-content li {
    font-size: 0.9rem;
    color: var(--gray-600);
    margin-bottom: 0.25rem;
}

.flow-arrow {
    color: var(--primary-400);
    font-size: 1.5rem;
}

.downgrade-factors,
.upgrade-factors {
    display: flex;
    flex-direction: column;
    gap: 1.5rem;
}

.upgrade-intro {
    background: linear-gradient(135deg, #d4edda, #c3e6cb);
    padding: 1rem 1.5rem;
    border-radius: 8px;
    margin-bottom: 1rem;
    border-left: 4px solid #28a745;
}

.upgrade-intro p {
    margin: 0;
    color: #155724;
    display: flex;
    align-items: flex-start;
    gap: 0.75rem;
}

.factor-card {
    border-radius: 12px;
    overflow: hidden;
    border: 2px solid;
}

.factor-card.downgrade {
    border-color: #dc3545;
}

.factor-card.upgrade {
    border-color: #28a745;
}

.factor-header {
    display: flex;
    align-items: center;
    gap: 1rem;
    padding: 1.25rem 1.5rem;
}

.factor-card.downgrade .factor-header {
    background: linear-gradient(135deg, #f8d7da, #f5c6cb);
}

.factor-card.upgrade .factor-header {
    background: linear-gradient(135deg, #d4edda, #c3e6cb);
}

.factor-number {
    width: 36px;
    height: 36px;
    border-radius: 50%;
    background: #dc3545;
    color: white;
    display: flex;
    align-items: center;
    justify-content: center;
    font-weight: bold;
    font-size: 1.1rem;
    flex-shrink: 0;
}

.factor-number.up {
    background: #28a745;
}

.factor-title h4 {
    margin: 0 0 0.25rem 0;
    color: var(--gray-800);
    font-size: 1.1rem;
}

.factor-subtitle {
    margin: 0;
    color: var(--gray-600);
    font-size: 0.9rem;
}

.factor-body {
    padding: 1.5rem;
    background: white;
}

.factor-definition {
    background: var(--gray-50);
    padding: 1rem;
    border-radius: 8px;
    margin-bottom: 1.25rem;
    border-left: 3px solid var(--primary-500);
}

.factor-assess {
    margin-bottom: 1.25rem;
}

.factor-assess > strong {
    display: block;
    margin-bottom: 0.75rem;
    color: var(--gray-700);
}

.factor-assess ul {
    margin: 0;
    padding-left: 1.25rem;
}

.factor-assess li {
    margin-bottom: 0.5rem;
    line-height: 1.5;
    color: var(--gray-600);
}

.factor-criteria {
    display: flex;
    flex-direction: column;
    gap: 0.75rem;
    margin-bottom: 1rem;
}

.criteria-item {
    display: flex;
    align-items: center;
    gap: 1rem;
    padding: 0.75rem 1rem;
    border-radius: 8px;
}

.criteria-item.serious {
    background: #fff3cd;
    border: 1px solid #ffc107;
}

.criteria-item.very-serious {
    background: #f8d7da;
    border: 1px solid #dc3545;
}

.criteria-label {
    font-weight: 600;
    white-space: nowrap;
    padding: 0.25rem 0.75rem;
    border-radius: 4px;
    font-size: 0.85rem;
}

.criteria-item.serious .criteria-label {
    background: #ffc107;
    color: #333;
}

.criteria-item.very-serious .criteria-label {
    background: #dc3545;
    color: white;
}

.criteria-desc {
    color: var(--gray-700);
    font-size: 0.9rem;
}

.factor-tip {
    background: #e7f3ff;
    border-radius: 8px;
    padding: 0.75rem 1rem;
    display: flex;
    align-items: flex-start;
    gap: 0.75rem;
    font-size: 0.85rem;
    color: #0056b3;
    border-left: 3px solid #007bff;
}

.factor-tip i {
    margin-top: 2px;
}

.factor-requirements {
    margin-top: 1rem;
}

.factor-requirements > strong {
    display: block;
    margin-bottom: 0.5rem;
    color: var(--gray-700);
}

.factor-requirements ul {
    margin: 0;
    padding-left: 1.25rem;
}

.factor-requirements li {
    margin-bottom: 0.35rem;
    color: var(--gray-600);
    font-size: 0.9rem;
}

.effect-size-criteria {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
    gap: 1rem;
    margin-top: 0.75rem;
}

.effect-item {
    background: #d4edda;
    border-radius: 8px;
    padding: 1rem;
    text-align: center;
    border: 1px solid #28a745;
}

.effect-label {
    font-weight: 600;
    color: #155724;
    margin-bottom: 0.5rem;
}

.effect-value {
    font-size: 1.25rem;
    font-weight: bold;
    color: #28a745;
    margin-bottom: 0.5rem;
    font-family: 'JetBrains Mono', monospace;
}

.effect-desc {
    font-size: 0.85rem;
    color: #155724;
}

.grade-table-container {
    overflow-x: auto;
}

.grade-reference-table {
    width: 100%;
    border-collapse: collapse;
    font-size: 0.9rem;
}

.grade-reference-table th,
.grade-reference-table td {
    padding: 0.75rem 1rem;
    text-align: left;
    border: 1px solid var(--gray-300);
}

.grade-reference-table th {
    background: var(--gray-700);
    color: white;
    font-weight: 600;
}

.grade-reference-table .downgrade-row {
    background: #fff5f5;
}

.grade-reference-table .upgrade-row {
    background: #f0fff4;
}

.grade-reference-table tr:hover {
    background: var(--gray-100);
}

.grade-reference-table .downgrade-row:hover {
    background: #ffe5e5;
}

.grade-reference-table .upgrade-row:hover {
    background: #e0ffe5;
}

.grade-resources {
    display: flex;
    flex-direction: column;
    gap: 0.75rem;
}

.grade-resources .resource-link {
    display: flex;
    align-items: center;
    gap: 0.75rem;
    padding: 1rem 1.25rem;
    background: var(--gray-50);
    border-radius: 8px;
    border: 1px solid var(--gray-200);
    text-decoration: none;
    color: var(--primary-700);
    font-weight: 500;
    transition: all 0.3s ease;
}

.grade-resources .resource-link:hover {
    background: var(--primary-50);
    border-color: var(--primary-300);
    transform: translateX(5px);
}

.grade-resources .resource-link i {
    font-size: 1.25rem;
    color: var(--primary-500);
    min-width: 24px;
}

@media (max-width: 768px) {
    .evidence-levels {
        grid-template-columns: 1fr;
    }

    .flow-step {
        flex-direction: column;
        gap: 1rem;
    }

    .step-number {
        align-self: flex-start;
    }

    .effect-size-criteria {
        grid-template-columns: 1fr;
    }

    .criteria-item {
        flex-direction: column;
        align-items: flex-start;
        gap: 0.5rem;
    }

    .grade-reference-table {
        font-size: 0.8rem;
    }

    .grade-reference-table th,
    .grade-reference-table td {
        padding: 0.5rem;
    }
}

.rob-content {
    display: flex;
    flex-direction: column;
    gap: 3rem;
}

.rob-section {
    background: white;
    border-radius: 12px;
    padding: 2rem;
    box-shadow: 0 4px 12px rgba(0,0,0,0.1);
    border: 1px solid var(--gray-200);
}

.rob-section h3 {
    color: var(--gray-600);
    margin-bottom: 2rem;
    display: flex;
    align-items: center;
    gap: 0.5rem;
    font-size: 1.3rem;
}

.rob-intro {
    display: flex;
    flex-direction: column;
    gap: 2rem;
}

.intro-card {
    background: white;
    border-radius: 12px;
    color: var(--gray-800);
    padding: 2rem;
    box-shadow: 0 4px 12px rgba(0, 0, 0, 0.1);
    border: 1px solid var(--gray-200);
}

.intro-content p {
    font-size: 1.1rem;
    line-height: 1.6;
    margin-bottom: 2rem;
}

.intro-highlights {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(250px, 1fr));
    gap: 1.5rem;
}

.highlight-item {
    display: flex;
    align-items: flex-start;
    gap: 1rem;
    background: var(--gray-50);
    padding: 1.5rem;
    border-radius: 8px;
    border: 1px solid var(--gray-200);
}

.highlight-item i {
    font-size: 2rem;
    color: var(--primary-600);
    min-width: 40px;
}

.highlight-item strong {
    display: block;
    margin-bottom: 0.5rem;
    font-size: 1.1rem;
}

.highlight-item p {
    margin: 0;
    font-size: 0.9rem;
    opacity: 0.9;
}

.domains-overview {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
    gap: 2rem;
}

.domain-card {
    border-radius: 12px;
    padding: 2rem;
    border: 2px solid;
    transition: transform 0.3s ease, box-shadow 0.3s ease;
    display: flex;
    gap: 1.5rem;
}

.domain-card:hover {
    transform: translateY(-5px);
    box-shadow: 0 8px 24px rgba(0,0,0,0.15);
}

.domain-card.domain-1 {
    border-color: #007bff;
    background: linear-gradient(135deg, #f0f8ff, #cce5ff);
}

.domain-card.domain-2 {
    border-color: var(--success);
    background: linear-gradient(135deg, #f0fff4, #d4edda);
}

.domain-card.domain-3 {
    border-color: var(--warning);
    background: linear-gradient(135deg, #fffbf0, #fff3cd);
}

.domain-card.domain-4 {
    border-color: #fd7e14;
    background: linear-gradient(135deg, #fff8f0, #ffe4cc);
}

.domain-card.domain-5 {
    border-color: #e83e8c;
    background: linear-gradient(135deg, #fff0f6, #f8d7da);
}

.domain-icon {
    font-size: 3rem;
    color: var(--gray-600);
    min-width: 60px;
    text-align: center;
    display: flex;
    align-items: center;
    justify-content: center;
}

.domain-content h4 {
    color: var(--gray-600);
    margin-bottom: 0.5rem;
    font-size: 1.2rem;
}

.domain-content p {
    color: var(--gray-500);
    font-style: italic;
    margin-bottom: 1rem;
    font-size: 0.9rem;
}

.domain-content ul {
    list-style: none;
    padding: 0;
    margin: 0;
}

.domain-content li {
    position: relative;
    padding-left: 1.2rem;
    margin-bottom: 0.5rem;
    color: var(--gray-600);
    font-size: 0.9rem;
}

.domain-content li::before {
    content: "▸";
    position: absolute;
    left: 0;
    color: var(--primary-600);
    font-weight: bold;
}

.domain-number {
    position: absolute;
    top: -10px;
    right: -10px;
    background: var(--gray-700);
    color: white;
    width: 36px;
    height: 36px;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-weight: bold;
    font-size: 0.9rem;
    box-shadow: 0 2px 8px rgba(0,0,0,0.2);
}

.domain-card {
    position: relative;
}

.domain-card.domain-1 .domain-number {
    background: #007bff;
}

.domain-card.domain-2 .domain-number {
    background: var(--success);
}

.domain-card.domain-3 .domain-number {
    background: var(--warning);
    color: var(--gray-800);
}

.domain-card.domain-4 .domain-number {
    background: #fd7e14;
}

.domain-card.domain-5 .domain-number {
    background: #e83e8c;
}

.domain-en {
    color: var(--gray-500);
    font-style: italic;
    font-size: 0.85rem;
    margin-bottom: 1rem;
}

.domain-description {
    margin-bottom: 1rem;
}

.domain-description p {
    font-style: normal;
    color: var(--gray-700);
    margin-bottom: 0.75rem;
}

.domain-description ul {
    margin-top: 0.5rem;
}

.domain-description li {
    margin-bottom: 0.75rem;
    line-height: 1.5;
}

.domain-tip {
    background: rgba(255, 255, 255, 0.7);
    border-radius: 8px;
    padding: 0.75rem 1rem;
    display: flex;
    align-items: flex-start;
    gap: 0.75rem;
    font-size: 0.85rem;
    color: var(--gray-600);
    border-left: 3px solid var(--primary-500);
}

.domain-tip i {
    color: var(--warning);
    font-size: 1rem;
    margin-top: 2px;
}

.judgment-criteria h4,
.effect-types h4,
.resources h4 {
    display: flex;
    align-items: center;
    gap: 0.75rem;
    margin-bottom: 1.5rem;
    color: var(--gray-700);
    font-size: 1.15rem;
}

.judgment-levels {
    display: flex;
    flex-direction: column;
    gap: 1rem;
}

.judgment-item {
    display: flex;
    align-items: flex-start;
    gap: 1rem;
    padding: 1.25rem;
    border-radius: 10px;
    border: 1px solid;
}

.judgment-item.low-risk {
    background: linear-gradient(135deg, #d4edda, #c3e6cb);
    border-color: #28a745;
}

.judgment-item.some-concerns {
    background: linear-gradient(135deg, #fff3cd, #ffeeba);
    border-color: #ffc107;
}

.judgment-item.high-risk {
    background: linear-gradient(135deg, #f8d7da, #f5c6cb);
    border-color: #dc3545;
}

.judgment-icon {
    font-size: 1.75rem;
    min-width: 40px;
}

.judgment-item.low-risk .judgment-icon {
    color: #28a745;
}

.judgment-item.some-concerns .judgment-icon {
    color: #856404;
}

.judgment-item.high-risk .judgment-icon {
    color: #dc3545;
}

.judgment-content strong {
    display: block;
    margin-bottom: 0.5rem;
    font-size: 1.05rem;
}

.judgment-content p {
    margin: 0;
    font-size: 0.9rem;
    line-height: 1.5;
    color: var(--gray-700);
}

.effect-types > p {
    margin-bottom: 1rem;
    color: var(--gray-600);
}

.effect-type-options {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(280px, 1fr));
    gap: 1rem;
}

.effect-type-item {
    background: var(--gray-50);
    padding: 1.25rem;
    border-radius: 10px;
    border: 1px solid var(--gray-200);
}

.effect-type-item strong {
    display: flex;
    align-items: center;
    gap: 0.5rem;
    margin-bottom: 0.75rem;
    color: var(--primary-700);
}

.effect-type-item p {
    margin: 0;
    font-size: 0.9rem;
    color: var(--gray-600);
    line-height: 1.5;
}

.resource-links {
    display: flex;
    flex-direction: column;
    gap: 0.75rem;
}

.resource-link {
    display: flex;
    align-items: center;
    gap: 0.75rem;
    padding: 1rem 1.25rem;
    background: var(--gray-50);
    border-radius: 8px;
    border: 1px solid var(--gray-200);
    text-decoration: none;
    color: var(--primary-700);
    font-weight: 500;
    transition: all 0.3s ease;
}

.resource-link:hover {
    background: var(--primary-50);
    border-color: var(--primary-300);
    transform: translateX(5px);
}

.resource-link i {
    font-size: 1.25rem;
    color: var(--primary-500);
    min-width: 24px;
}

.help-content {
    background: var(--gray-50);
    border-radius: 12px;
    padding: 2rem;
}

.help-content {
    padding: 1.5rem;
    display: none;
    background: white;
}

.help-content.active {
    display: block;
}

.help-content ol,
.help-content ul {
    padding-left: 1.5rem;
}

.help-content li {
    margin-bottom: 0.5rem;
    line-height: 1.6;
    color: var(--gray-600);
}

.tips-container {
    background: var(--gray-50);
    border-radius: 12px;
    padding: 2rem;
}

.help-tips-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(280px, 1fr));
    gap: 1.25rem;
}

.tip-content strong {
    display: block;
    margin-bottom: 0.5rem;
    color: var(--gray-700);
    font-size: 1rem;
}

.tip-content p {
    margin: 0;
    font-size: 0.9rem;
    color: var(--gray-600);
    line-height: 1.5;
}

@media (max-width: 768px) {
    button {
        min-height: 44px;
        min-width: 44px;
        padding: 12px 16px;
        font-size: 14px;
        touch-action: manipulation;
    }

    input[type="text"],
    input[type="number"],
    select {
        min-height: 44px;
        padding: 10px 12px;
        font-size: 16px;
        width: 100%;
    }

    .table-responsive {
        overflow-x: auto;
        -webkit-overflow-scrolling: touch;
        margin: 0 -1rem;
        padding: 0 1rem;
    }

    table {
        min-width: 600px;
    }
}

@media (hover: none) and (pointer: coarse) {
    button,
    [role="button"] {
        min-height: 44px;
        min-width: 44px;
    }

    button:hover {
        transform: none;
        box-shadow: none;
    }

    button:active {
        opacity: 0.8;
        transform: scale(0.98);
    }
}

.scrollable-container {
    overflow-x: auto;
    -webkit-overflow-scrolling: touch;
    scroll-behavior: smooth;
    position: relative;
}

.scrollable-container::-webkit-scrollbar {
    height: 4px;
}

.scrollable-container::-webkit-scrollbar-track {
    background: var(--gray-100);
}

.scrollable-container::-webkit-scrollbar-thumb {
    background: var(--gray-400);
    border-radius: 2px;
}

.table-responsive {
    position: relative;
}

.table-responsive::before,
.table-responsive::after {
    content: '';
    position: absolute;
    top: 0;
    bottom: 0;
    width: 20px;
    pointer-events: none;
    z-index: 10;
    opacity: 0;
    transition: opacity 0.3s ease;
}

.table-responsive::before {
    left: 0;
    background: linear-gradient(to right, rgba(255,255,255,0.9), transparent);
}

.table-responsive::after {
    right: 0;
    background: linear-gradient(to left, rgba(255,255,255,0.9), transparent);
}

.table-responsive.scrolled-left::before {
    opacity: 1;
}

.table-responsive.can-scroll-right::after {
    opacity: 1;
}

@media print {
    button {
        display: none !important;
    }
}

.es-value {
    font-family: var(--font-mono);
    font-weight: 600;
    font-size: 0.9rem;
    color: var(--gray-800);
    min-width: 70px;
}

.forest-plot-guide {
    display: flex;
    flex-direction: column;
    gap: var(--space-6);
}

.forest-intro {
    background: var(--gray-50);
    padding: var(--space-4);
    border-radius: var(--radius);
    border-left: 4px solid var(--primary-500);
}

.forest-intro p {
    margin: 0;
    color: var(--gray-700);
    line-height: 1.6;
}

.forest-elements h4,
.interpretation-steps h4,
.interpretation-scenarios h4,
.forest-warnings h4 {
    display: flex;
    align-items: center;
    gap: 10px;
    color: var(--gray-800);
    margin-bottom: var(--space-4);
}

.forest-elements h4 i,
.interpretation-steps h4 i,
.interpretation-scenarios h4 i,
.forest-warnings h4 i {
    color: var(--primary-500);
}

.elements-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(220px, 1fr));
    gap: var(--space-4);
}

.element-card {
    background: white;
    border-radius: var(--radius);
    padding: var(--space-4);
    box-shadow: var(--shadow);
    display: flex;
    gap: var(--space-3);
    transition: transform 0.2s ease;
}

.element-card:hover {
    transform: translateY(-2px);
}

.element-icon {
    width: 50px;
    height: 50px;
    background: linear-gradient(135deg, var(--primary-100) 0%, var(--primary-200) 100%);
    border-radius: var(--radius);
    display: flex;
    align-items: center;
    justify-content: center;
    flex-shrink: 0;
}

.element-icon i {
    font-size: 1.25rem;
    color: var(--primary-600);
}

.element-content h5 {
    margin: 0 0 6px 0;
    color: var(--gray-800);
    font-size: 0.95rem;
}

.element-content p {
    margin: 0;
    color: var(--gray-600);
    font-size: 0.85rem;
    line-height: 1.4;
}

.element-note {
    margin-top: 6px !important;
    color: var(--primary-600) !important;
    font-size: 0.8rem !important;
}

.steps-container {
    display: flex;
    flex-direction: column;
    gap: var(--space-3);
}

.step-item {
    display: flex;
    gap: var(--space-4);
    background: white;
    padding: var(--space-4);
    border-radius: var(--radius);
    box-shadow: var(--shadow);
}

.step-number {
    width: 40px;
    height: 40px;
    background: linear-gradient(135deg, var(--primary-500) 0%, var(--primary-600) 100%);
    color: white;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-weight: 700;
    font-size: 1.1rem;
    flex-shrink: 0;
}

.step-content h5 {
    margin: 0 0 8px 0;
    color: var(--gray-800);
}

.step-content ul {
    margin: 0;
    padding-left: var(--space-5);
    color: var(--gray-600);
}

.step-content li {
    margin-bottom: 4px;
    font-size: 0.9rem;
}

.scenarios-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(260px, 1fr));
    gap: var(--space-4);
}

.scenario-box {
    border-radius: var(--radius);
    padding: var(--space-4);
    box-shadow: var(--shadow);
}

.scenario-box.favorable {
    background: linear-gradient(135deg, #ecfdf5 0%, #d1fae5 100%);
    border: 1px solid #a7f3d0;
}

.scenario-box.mixed {
    background: linear-gradient(135deg, #fffbeb 0%, #fef3c7 100%);
    border: 1px solid #fde68a;
}

.scenario-box.problematic {
    background: linear-gradient(135deg, #fef2f2 0%, #fee2e2 100%);
    border: 1px solid #fecaca;
}

.scenario-header {
    display: flex;
    align-items: center;
    gap: 8px;
    margin-bottom: var(--space-3);
}

.scenario-header h5 {
    margin: 0;
    font-size: 1rem;
}

.scenario-box.favorable .scenario-header i {
    color: #059669;
}

.scenario-box.mixed .scenario-header i {
    color: #d97706;
}

.scenario-box.problematic .scenario-header i {
    color: #dc2626;
}

.scenario-box ul {
    margin: 0;
    padding-left: var(--space-5);
    font-size: 0.9rem;
    color: var(--gray-700);
}

.scenario-box li {
    margin-bottom: 4px;
}

.scenario-result {
    margin-top: var(--space-3);
    font-weight: 600;
    font-size: 0.9rem;
}

.scenario-box.favorable .scenario-result {
    color: #059669;
}

.scenario-box.mixed .scenario-result {
    color: #d97706;
}

.scenario-box.problematic .scenario-result {
    color: #dc2626;
}

.forest-warnings {
    background: linear-gradient(135deg, var(--info) 0%, var(--accent-600) 100%);
    padding: var(--space-4);
    border-radius: var(--radius);
    color: white;
}

.forest-warnings h4 {
    color: white;
    margin-bottom: var(--space-4);
}

.forest-warnings h4 i {
    color: #fef3c7;
}

.warnings-list {
    display: flex;
    flex-direction: column;
    gap: var(--space-3);
}

.warning-item {
    display: flex;
    align-items: flex-start;
    gap: 10px;
}

.warning-item i {
    color: #a5f3fc;
    margin-top: 2px;
}

.warning-item p {
    margin: 0;
    font-size: 0.9rem;
    line-height: 1.5;
}

.warning-item strong {
    color: #fef3c7;
}

@media (max-width: 768px) {
    .elements-grid {
        grid-template-columns: 1fr;
    }

    .scenarios-grid {
        grid-template-columns: 1fr;
    }

    .step-item {
        flex-direction: column;
        align-items: flex-start;
    }
}

.section-intro {
    color: var(--gray-600);
    margin-bottom: var(--space-6);
    line-height: 1.6;
}

.heterogeneity-decision-tree {
    display: flex;
    flex-direction: column;
    align-items: center;
    gap: var(--space-4);
}

.decision-level {
    width: 100%;
    display: flex;
    justify-content: center;
}

.decision-start {
    background: linear-gradient(135deg, #ef4444 0%, #dc2626 100%);
    color: white;
    padding: var(--space-4) var(--space-6);
    border-radius: var(--radius);
    text-align: center;
    box-shadow: var(--shadow-md);
}

.decision-start i {
    font-size: 1.5rem;
    margin-bottom: 8px;
    display: block;
}

.decision-start h4 {
    margin: 0;
    font-size: 1.1rem;
}

.decision-arrow-down {
    color: var(--gray-400);
    font-size: 1.5rem;
}

.decision-question {
    background: var(--gray-100);
    padding: var(--space-3) var(--space-6);
    border-radius: var(--radius);
    border: 2px solid var(--gray-300);
}

.decision-question h5 {
    margin: 0;
    color: var(--gray-700);
    font-size: 1rem;
}

.decision-branches {
    display: grid;
    grid-template-columns: 1fr 1fr;
    gap: var(--space-4);
    width: 100%;
    max-width: 800px;
}

.decision-branch {
    background: white;
    border-radius: var(--radius);
    overflow: hidden;
    box-shadow: var(--shadow);
}

.branch-header {
    padding: var(--space-3);
    font-weight: 600;
    text-align: center;
}

.branch-header.yes {
    background: linear-gradient(135deg, #10b981 0%, #059669 100%);
    color: white;
}

.branch-header.no {
    background: linear-gradient(135deg, #f59e0b 0%, #d97706 100%);
    color: white;
}

.branch-content {
    padding: var(--space-4);
}

.branch-content p {
    margin: 0 0 var(--space-3) 0;
    color: var(--gray-600);
    font-size: 0.9rem;
}

.branch-action {
    display: flex;
    align-items: center;
    gap: 8px;
    padding: var(--space-2) var(--space-3);
    background: var(--primary-50);
    border-radius: var(--radius-sm);
    color: var(--primary-700);
    font-size: 0.85rem;
}

.branch-action.warning {
    background: #fef3c7;
    color: #92400e;
}

.source-exploration {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(240px, 1fr));
    gap: var(--space-4);
    width: 100%;
}

.source-category {
    background: white;
    border-radius: var(--radius);
    overflow: hidden;
    box-shadow: var(--shadow);
}

.source-header {
    padding: var(--space-3);
    display: flex;
    align-items: center;
    gap: 10px;
    color: white;
}

.source-header h6 {
    margin: 0;
    font-size: 0.95rem;
}

.source-header.clinical {
    background: linear-gradient(135deg, var(--primary-500) 0%, var(--primary-600) 100%);
}

.source-header.methodological {
    background: linear-gradient(135deg, var(--accent-500) 0%, var(--accent-600) 100%);
}

.source-header.statistical {
    background: linear-gradient(135deg, #8b5cf6 0%, #7c3aed 100%);
}

.source-category ul {
    padding: var(--space-3) var(--space-4);
    margin: 0;
    list-style: none;
}

.source-category li {
    padding: var(--space-2) 0;
    border-bottom: 1px solid var(--gray-100);
    font-size: 0.85rem;
    color: var(--gray-600);
}

.source-category li:last-child {
    border-bottom: none;
}

.strategy-options {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
    gap: var(--space-4);
    width: 100%;
}

.strategy-card {
    background: white;
    border-radius: var(--radius);
    padding: var(--space-4);
    text-align: center;
    box-shadow: var(--shadow);
    transition: transform 0.2s ease;
}

.strategy-card:hover {
    transform: translateY(-3px);
}

.strategy-icon {
    width: 50px;
    height: 50px;
    background: linear-gradient(135deg, var(--primary-100) 0%, var(--primary-200) 100%);
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    margin: 0 auto var(--space-3) auto;
}

.strategy-icon i {
    font-size: 1.25rem;
    color: var(--primary-600);
}

.strategy-card h6 {
    margin: 0 0 8px 0;
    color: var(--gray-800);
    font-size: 1rem;
}

.strategy-card p {
    margin: 0 0 var(--space-3) 0;
    color: var(--gray-500);
    font-size: 0.85rem;
}

.strategy-when {
    background: var(--gray-50);
    padding: var(--space-2);
    border-radius: var(--radius-sm);
    font-size: 0.8rem;
    color: var(--gray-600);
}

.heterogeneity-reminder {
    background: linear-gradient(135deg, var(--info) 0%, var(--accent-600) 100%);
    color: white;
    padding: var(--space-4);
    border-radius: var(--radius);
    display: flex;
    gap: var(--space-4);
    width: 100%;
    max-width: 800px;
}

.heterogeneity-reminder > i {
    font-size: 2rem;
    color: #fef3c7;
    flex-shrink: 0;
}

.reminder-content h6 {
    margin: 0 0 8px 0;
    color: #fef3c7;
    font-size: 1rem;
}

.reminder-content p {
    margin: 0;
    font-size: 0.9rem;
    line-height: 1.6;
}

@media (max-width: 768px) {
    .decision-branches {
        grid-template-columns: 1fr;
    }

    .source-exploration {
        grid-template-columns: 1fr;
    }

    .strategy-options {
        grid-template-columns: repeat(2, 1fr);
    }

    .heterogeneity-reminder {
        flex-direction: column;
        text-align: center;
    }
}

@media (max-width: 480px) {
    .strategy-options {
        grid-template-columns: 1fr;
    }
}

.prisma-guide {
    display: flex;
    flex-direction: column;
    gap: var(--space-6);
}

.prisma-intro {
    background: var(--gray-50);
    padding: var(--space-4);
    border-radius: var(--radius);
    border-left: 4px solid var(--primary-500);
}

.prisma-intro p {
    margin: 0;
    color: var(--gray-700);
    line-height: 1.6;
}

.prisma-flowchart h4,
.prisma-updates h4,
.prisma-tips h4,
.prisma-resources h4 {
    display: flex;
    align-items: center;
    gap: 10px;
    margin-bottom: var(--space-4);
    color: var(--gray-800);
}

.prisma-flowchart h4 i,
.prisma-updates h4 i,
.prisma-tips h4 i,
.prisma-resources h4 i {
    color: var(--primary-500);
}

.prisma-stage {
    background: white;
    border-radius: var(--radius);
    overflow: hidden;
    box-shadow: var(--shadow);
    margin-bottom: var(--space-4);
}

.stage-header {
    display: flex;
    align-items: center;
    gap: var(--space-3);
    padding: var(--space-3) var(--space-4);
    color: white;
}

.prisma-stage.identification .stage-header {
    background: linear-gradient(135deg, #3b82f6 0%, #2563eb 100%);
}

.prisma-stage.screening .stage-header {
    background: linear-gradient(135deg, #8b5cf6 0%, #7c3aed 100%);
}

.prisma-stage.included .stage-header {
    background: linear-gradient(135deg, #10b981 0%, #059669 100%);
}

.stage-number {
    width: 32px;
    height: 32px;
    background: rgba(255, 255, 255, 0.2);
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-weight: 700;
    font-size: 1rem;
}

.stage-header h5 {
    margin: 0;
    font-size: 1rem;
}

.stage-content {
    padding: var(--space-4);
}

.stage-boxes {
    display: grid;
    grid-template-columns: 1fr 1fr;
    gap: var(--space-4);
    margin-bottom: var(--space-4);
}

.stage-box {
    background: var(--gray-50);
    padding: var(--space-3);
    border-radius: var(--radius-sm);
}

.stage-box h6 {
    margin: 0 0 8px 0;
    color: var(--gray-800);
    font-size: 0.9rem;
}

.stage-box ul {
    margin: 0;
    padding-left: var(--space-4);
    font-size: 0.85rem;
    color: var(--gray-600);
}

.stage-box li {
    margin-bottom: 4px;
}

.stage-action {
    display: flex;
    align-items: center;
    justify-content: center;
    gap: 10px;
    padding: var(--space-2);
    background: var(--primary-50);
    border-radius: var(--radius-sm);
    color: var(--primary-700);
    font-size: 0.9rem;
}

.screening-steps {
    display: flex;
    flex-direction: column;
    gap: var(--space-3);
}

.screening-step {
    display: flex;
    align-items: center;
    gap: var(--space-4);
    padding: var(--space-3);
    background: var(--gray-50);
    border-radius: var(--radius-sm);
}

.step-main {
    flex: 1;
}

.step-main strong {
    display: block;
    margin-bottom: 4px;
    color: var(--gray-800);
}

.step-main p {
    margin: 0;
    font-size: 0.85rem;
    color: var(--gray-600);
}

.step-excluded {
    display: flex;
    align-items: center;
    gap: 6px;
    padding: var(--space-2) var(--space-3);
    background: #fef2f2;
    border-radius: var(--radius-sm);
    color: #dc2626;
    font-size: 0.8rem;
}

.included-details {
    display: flex;
    flex-direction: column;
    align-items: center;
    gap: var(--space-3);
}

.included-box {
    width: 100%;
    padding: var(--space-3);
    background: var(--gray-50);
    border-radius: var(--radius-sm);
    text-align: center;
}

.included-box.highlight {
    background: linear-gradient(135deg, var(--primary-50) 0%, var(--primary-100) 100%);
    border: 2px solid var(--primary-300);
}

.included-box h6 {
    margin: 0 0 4px 0;
    color: var(--gray-800);
}

.included-box p {
    margin: 0;
    font-size: 0.85rem;
    color: var(--gray-600);
}

.included-arrow {
    color: var(--gray-400);
    font-size: 1.25rem;
}

.updates-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(280px, 1fr));
    gap: var(--space-4);
}

.update-item {
    display: flex;
    gap: var(--space-3);
    padding: var(--space-3);
    background: white;
    border-radius: var(--radius);
    box-shadow: var(--shadow);
}

.update-item > i {
    color: var(--success);
    font-size: 1.25rem;
    flex-shrink: 0;
}

.update-item strong {
    display: block;
    margin-bottom: 4px;
    color: var(--gray-800);
}

.update-item p {
    margin: 0;
    font-size: 0.85rem;
    color: var(--gray-600);
}

.prisma-tips {
    background: linear-gradient(135deg, var(--info) 0%, var(--accent-600) 100%);
    padding: var(--space-4);
    border-radius: var(--radius);
    color: white;
}

.prisma-tips h4 {
    color: white;
    margin-bottom: var(--space-3);
}

.prisma-tips h4 i {
    color: #fef3c7;
}

.prisma-tips ul {
    margin: 0;
    padding-left: var(--space-5);
}

.prisma-tips li {
    margin-bottom: 8px;
    line-height: 1.5;
}

.prisma-tips strong {
    color: #fef3c7;
}

.prisma-resources {
    background: var(--gray-50);
    padding: var(--space-4);
    border-radius: var(--radius);
}

.resource-links {
    display: flex;
    flex-wrap: wrap;
    gap: var(--space-3);
}

.resource-link {
    display: flex;
    align-items: center;
    gap: 8px;
    padding: var(--space-2) var(--space-4);
    background: white;
    border: 1px solid var(--gray-200);
    border-radius: var(--radius);
    color: var(--primary-600);
    text-decoration: none;
    font-size: 0.9rem;
    transition: all 0.2s ease;
}

.resource-link:hover {
    background: var(--primary-50);
    border-color: var(--primary-300);
    transform: translateY(-2px);
}

.resource-link i {
    color: var(--primary-500);
}

@media (max-width: 768px) {
    .stage-boxes {
        grid-template-columns: 1fr;
    }

    .screening-step {
        flex-direction: column;
        align-items: flex-start;
    }

    .step-excluded {
        align-self: flex-end;
    }

    .updates-grid {
        grid-template-columns: 1fr;
    }

    .resource-links {
        flex-direction: column;
    }
}

@media (max-width: 480px) {
    .decision-branches-enhanced,
    .outcome-grid,
    .principles-grid,
    .effect-comparison,
    .binary-measures-grid,
    .survival-details,
    .conversion-scenarios,
    .tau-grid,
    .factors-grid,
    .intro-highlights,
    .effect-type-options,
    .domains-overview,
    .help-tips-grid,
    .reference-grid {
        grid-template-columns: minmax(0, 1fr);
    }

    .reference-card,
    .domain-content,
    .factor-group,
    .highlight-item > div {
        min-width: 0;
    }

    .intro-card {
        padding: 1rem;
    }

    .grade-intro {
        padding: 1rem;
    }

    .scale-item {
        flex-wrap: wrap;
        gap: 0.5rem;
    }

    .scale-label {
        margin: 0;
        min-width: 0;
    }

    .scale-range,
    .tree-box {
        min-width: 0;
    }
}